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Colossal Biosciences Revives Dire Wolf Traits Through Genetic Engineering

The Dallas-based company has successfully created three genetically modified wolves resembling the extinct dire wolf, fueling scientific, ethical, and cultural discussions.

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A genetically modified wolf pup, one of three successfully bred by reconstructing a genome from the ancient DNA of fossils from the long-extinct dire wolf, is bottle fed at 15 days old in north Texas, U.S.  Colossal Biosciences/Handout via REUTERS.

Overview

  • Colossal Biosciences announced the birth of three genetically engineered wolf pups, Khaleesi, Romulus, and Remus, designed to exhibit traits of the extinct dire wolf species.
  • The dire wolves were recreated by editing gray wolf DNA, reintroducing physical traits such as larger size and thicker manes, though some scientists argue they are not true dire wolves.
  • George R.R. Martin, author of A Song of Ice and Fire, is an investor and cultural advisor on the project and expressed deep emotional connection upon meeting the wolves.
  • The de-extinction effort has sparked ethical and ecological concerns, with comparisons to Jurassic Park highlighting potential risks of genetic manipulation.
  • Colossal Biosciences plans to expand its de-extinction work to other species like the woolly mammoth, dodo bird, and Tasmanian tiger, while its technology has already contributed to conservation efforts for endangered species like the red wolf.