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Colorado Upsets No. 22 Iowa State 24-17 for First Big 12 Win of 2025

Fourth-quarter takeaways sealed Colorado's first conference victory of the season, with Kaidon Salter delivering a clean two-touchdown bounce-back.

Head coach Deion Sanders of the Colorado Buffaloes walks on the field during the Black and Gold Spring Game at Folsom Field on April 19, 2025 in Boulder, Colorado.
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Omarion Miller #4 of the Colorado Buffaloes celebrates after catching a touchdown pass during the second half against the TCU Horned Frogs at Amon G. Carter Stadium on October 4, 2025 in Fort Worth, Texas.

Overview

  • The Buffaloes improved to 3-4 (1-3 Big 12) with their first ranked home win since 2019, while Iowa State fell to 5-2 (2-2).
  • Kaidon Salter went 16-of-25 for 255 yards and two touchdowns, hitting Omarion Miller for a 70-yard score and Joseph Williams for a TD plus a late 38-yard dagger; Williams finished with eight catches for 128 yards.
  • Colorado’s defense flipped the game with Tawfiq Byard’s red-zone interception after officials waived off a flag, then stuffed a fourth-and-1 at the Cyclones’ 18 to set up Alejandro Mata’s 29-yard field goal.
  • Iowa State’s Abu Sama III ran for 177 yards and two touchdowns, but the Cyclones committed seven penalties and Rocco Becht finished with 205 passing yards, no touchdowns and one interception.
  • Deion Sanders coached on the sideline days after a blood-clot procedure as a short-handed Colorado (17 players out) closed it out before a field rush by students.