Overview

• The study reviewed over 8,400 colonoscopy records in Australia to assess polyp-related cancer risk.
• Patients with both adenomas and serrated polyps faced up to a fivefold greater likelihood of advanced precancerous changes than those with a single lesion type.
• Almost half of individuals diagnosed with serrated polyps were also found to have adenomas, expanding the high-risk cohort.
• Serrated polyps showed faster progression toward malignancy compared with adenomas, highlighting distinct oncogenic pathways.
• Colorectal cancer remains Australia’s second deadliest and fourth most common newly diagnosed cancer, underscoring the need for improved early detection.