Overview
- The analysis pooled 12 randomized trials with 22,983 participants who had prior cardiovascular disease.
- Participants took 0.5 mg of colchicine once or twice daily for at least six months alongside usual care.
- For every 1,000 people treated, the review estimates nine fewer heart attacks and eight fewer strokes versus controls.
- Mild gastrointestinal complaints were more frequent among users, with no increase in serious adverse events reported.
- Evidence remains uncertain for effects on overall mortality, revascularization, hospital stays, and quality of life, and most trial participants were older men.