Overview

• The Cilento Initiative on Aging Outcomes (CIAO) study, launched in 2016, investigates biological, psychological, and social factors enabling extreme longevity in Cilento, Italy.
• Researchers have identified preserved microcirculation, favorable cardiovascular profiles, and robust cognitive function among centenarians as key health markers.
• Psychological traits such as resilience, optimism, and strong social bonds are linked to mental well-being despite physical aging in nonagenarians.
• Advanced technologies like iPSC-derived organoids and multi-omics analyses are being used to explore cellular mechanisms of aging and potential therapeutic targets.
• A symposium on May 22-23 in Acciaroli will showcase emerging findings and outline future research directions for healthy aging and regenerative medicine.