Overview

• Marijuana smokers experienced a 42% reduction in arterial dilation while THC-edible users saw a 56% drop compared to nonusers.
• Lab experiments showed smoke exposure suppressed endothelial nitric oxide production, whereas edibles impaired vascular health through distinct metabolic pathways.
• Frequency of cannabis consumption correlated with progressively worse endothelial function, indicating a clear dose–response effect.
• Vascular impairment in cannabis users mirrored that of tobacco smokers, suggesting combined harms from smoke and THC.
• The American Heart Association advises against smoking or vaping any substance, and experts call for larger long-term studies to establish safe use guidelines.