Overview

• Christina Applegate, diagnosed with multiple sclerosis in 2021, says her symptoms have intensified significantly, confining her largely to her home.
• Speaking on Conan O'Brien's podcast, Applegate described her MS as 'the worst thing' she has ever experienced and detailed the severe pain and balance issues she faces daily.
• The actress has undergone over 30 clinical treatments to manage her condition but continues to struggle with debilitating side effects, including pain and nausea.
• Applegate uses her platform, including the 'MeSsy' podcast co-hosted with Jamie-Lynn Sigler, to raise awareness about MS and combat stigma surrounding the disease.
• She has expressed frustration with misconceptions about MS, particularly questions implying personal fault in contracting the illness.