Overview

• Applegate revealed she rarely leaves her home due to the debilitating effects of multiple sclerosis, describing her daily life as 'really, really hard.'
• She has been hospitalized over 30 times since her 2021 diagnosis, citing 'unimaginable' pain and severe relapses as key challenges.
• The Emmy-winning actress described living with MS as 'the worst thing' she has ever experienced, both physically and emotionally.
• Applegate continues to confront societal stigma and misinformation, including unsolicited 'cure' suggestions and questions about whether she caused her illness.
• Through her MeSsy podcast with Jamie-Lynn Sigler, Applegate advocates for disability representation and raises awareness about the realities of MS.