Overview
- Applegate announced on her MeSsy podcast that clinicians have concluded she does not have multiple sclerosis after reanalysis of prior tests using updated imaging and laboratory review.
- She said the news has not eased her symptoms and described severe mobility limits and pain, including taking long periods to get out of bed and using a walker for short distances.
- Applegate plans to begin further evaluation with a rheumatologist and said clinicians will continue to review prior tests while exploring other specialist referrals if needed.
- Her co-host Jamie-Lynn Sigler framed the podcast episode as part of a broader conversation about how hard it can be to reach a correct diagnosis for autoimmune and neurological conditions.
- The case highlights limits in MS diagnosis and the role of newer imaging markers and specialist review in reducing misdiagnosis, which published estimates place in the mid-teens percent for initial MS diagnoses.