Overview
- Applegate disclosed on Tuesday that doctors have concluded she was misdiagnosed with MS and told her she does not have the disease.
- Physicians paused her immunotherapy infusions to observe B‑cell responses, and those results prompted a multi‑year re‑evaluation that ended with the diagnosis being overturned.
- Despite the reversal, Applegate continues to have severe neurological symptoms and mobility limits, and she says the news has left her emotionally devastated and clinically without answers.
- A Cedars‑Sinai neurologist on the podcast noted that MS has no single definitive test and that studies place misdiagnosis rates in the roughly 15–20 percent range, which can expose patients to unnecessary long‑term treatments.
- Applegate’s medical team has launched further testing to identify an alternative cause and the case highlights broader consequences for patients, clinicians and advocates when diagnostic criteria and treatment responses prompt reappraisal.