Overview
- Applegate disclosed on Tuesday that her medical team told her she does not have multiple sclerosis after living with the diagnosis since 2021.
- Her doctors began re-evaluating the diagnosis when they paused an MS infusion to watch B‑cell response and found the expected immune changes did not occur.
- Despite the reversal, Applegate says her debilitating symptoms have not improved and she remains without an alternate diagnosis.
- She described a heavy emotional toll, saying the news left her depressed, out of work, and struggling with the loss of her role as an MS advocate.
- Neurologists on her podcast noted MS has no single definitive test and estimated misdiagnosis rates in the mid‑teens to about 20 percent, raising concerns about unnecessary long‑term treatments and the need for careful second opinions.