Overview
- Applegate disclosed on the MeSsY podcast on Tuesday that clinicians told her she was misdiagnosed with multiple sclerosis in 2021 and that the diagnosis has been overturned.
- Her medical team began re-evaluating the diagnosis after pausing infusion therapy to observe B‑cell responses and finding results that did not match expected MS biology.
- Despite the reversal, Applegate continues to experience debilitating symptoms including loss of mobility and pain, and she said her condition has not improved.
- Applegate described a severe emotional and professional toll from the diagnosis and its reversal, saying she fell into depression and lost work and a sense of purpose tied to MS advocacy.
- Experts on the podcast explained that no single test confirms MS and that studies put misdiagnosis rates in the mid‑teens to roughly 20 percent, raising questions about long‑term treatment and follow‑up testing for patients.