Overview
- Christina Applegate disclosed on Tuesday that her doctor told her she was misdiagnosed and does not have multiple sclerosis.
- She remains physically impaired and continues to use mobility aids, saying her symptoms have not improved since the original 2021 diagnosis.
- Clinicians began re‑evaluating her case after pausing certain infusions and running cell tests that produced unexpected results, but no alternate diagnosis has been announced.
- Neurologists on her podcast explained that MS has no single definitive test and cited published estimates that roughly 15 to 20 percent of initial MS diagnoses are later found to be incorrect.
- Applegate described severe emotional fallout from the reversal, including depression and a sense of lost purpose as an advocate, and doctors say the ongoing investigation will try to explain both the 2021 findings and her current symptoms.