Overview
- Applegate disclosed on Tuesday that her 2021 multiple sclerosis diagnosis has been overturned and clinicians no longer believe she has MS.
- On her MeSsy podcast she said she will investigate whether saline breast implants from a 2008 reconstruction are leaking and could explain MS-like symptoms, a theory that is unproven.
- Her doctors are conducting stepwise testing for conditions that can mimic MS, including rheumatoid arthritis, lupus and Lyme disease, and have paused or rechecked some treatments during the review.
- Applegate continues to report severe joint and mobility problems such as an immobile right shoulder and major pain that slows basic movements, and she described mounting emotional strain while navigating more tests.
- The case highlights limits in MS diagnosis because there is no single definitive test, underscores a known risk of initial misdiagnosis, and intersects with contested claims about breast implant illness that will require targeted specialist evaluation.