Overview

• On July 30, Applegate told Kelly Ripa’s SiriusXM podcast that her 14-year-old daughter Sadie said, “I missed who you were before you got sick.”
• The actress described hearing those words as “like a knife to the heart” and admitted she, too, mourns her pre-MS identity.
• Applegate credits Sadie as her primary motivation for facing the unpredictable pain, fatigue and mobility challenges of multiple sclerosis.
• Since revealing her 2021 diagnosis, she has used candid interviews and her MeSsy podcast with fellow MS survivor Jamie-Lynn Sigler to raise awareness and reduce stigma.
• The family’s journey encompasses husband Martyn LeNoble’s steadfast support and Sadie’s own POTS diagnosis, highlighting the shared emotional and practical adjustments.