Overview

• Applegate was diagnosed with multiple sclerosis in 2021 and has been candid about her condition.
• She describes experiencing a deep, debilitating depression that has affected her outlook on life.
• Applegate has recently sought therapy, despite her initial reluctance due to fear of emotional overwhelm.
• Public appearances, such as at the Emmys, have been physically and mentally exhausting for her.
• She uses humor and self-deprecation as coping mechanisms to make others more comfortable.