Christina Applegate Opens Up About Life with MS and Severe Depression

The actress shares her struggles with multiple sclerosis and its impact on her mental health on her podcast, MeSsy.

Applegate was diagnosed with multiple sclerosis in 2021 and has been candid about her condition.
She describes experiencing a deep, debilitating depression that has affected her outlook on life.
Applegate has recently sought therapy, despite her initial reluctance due to fear of emotional overwhelm.
Public appearances, such as at the Emmys, have been physically and mentally exhausting for her.
She uses humor and self-deprecation as coping mechanisms to make others more comfortable.