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Christina Applegate Faces Severe MS Symptoms Leading to Over 30 Hospitalizations

The actress continues to advocate for better understanding of MS while preparing for a colonoscopy to investigate potential motility issues linked to her symptoms.

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Christina Applegate and Sadie Grace LeNoble attend the 29th Annual Screen Actors Guild Awards at Fairmont Century Plaza on Feb. 26, 2023, in Los Angeles.

Overview

  • Christina Applegate has been hospitalized more than 30 times in three years due to severe vomiting, diarrhea, and pain related to multiple sclerosis (MS).
  • She suspects her gastrointestinal symptoms may be linked to motility issues caused by MS, though her neurologist has not confirmed this connection.
  • Applegate plans to undergo a colonoscopy on March 20, 2025, to further explore the potential cause of her symptoms.
  • Despite these challenges, she uses her 'MeSsy' podcast, co-hosted with Jamie-Lynn Sigler, to share her experiences and connect with others living with MS.
  • Applegate's candid discussions about her symptoms highlight the variability of MS and the importance of patient advocacy and transparency.