Overview

• Christina Applegate has been hospitalized more than 30 times in the past three years due to severe vomiting, diarrhea, and pain linked to her MS diagnosis.
• She suspects her gastrointestinal symptoms may be connected to motility issues caused by MS, though her neurologist disagrees.
• Applegate plans to undergo a colonoscopy on March 20, 2025, to further explore the potential connection and advocate for answers.
• She has used her podcast, 'MeSsy,' co-hosted with Jamie-Lynn Sigler, to candidly discuss her health challenges and connect with others living with MS.
• Despite the severity of her symptoms, Applegate maintains a sense of humor, referring to simultaneous vomiting and diarrhea episodes as 'double dragon.'