Overview

• Applegate felt severe, radiating pain on her flight home from a family trip in Europe and admitted herself to a Los Angeles hospital on August 5.
• Doctors ordered a 2 a.m. CT scan that confirmed the kidney infection had spread from one kidney to both.
• She recorded the latest episode of her MeSsy podcast from her hospital bed, blending dark humor with candid reflections on her pain and medical journey.
• Initial evaluations suspected a urinary tract infection and questioned her hygiene techniques, underscoring the diagnostic challenges she’s faced since her 2021 multiple sclerosis diagnosis.
• She will stay hospitalized for intravenous antibiotic treatment as physicians continue comprehensive testing to rule out further complications.