Overview

• McCaffrey missed four weeks of practice due to injuries but returned to limited practice this week.
• Coach Kyle Shanahan has not confirmed if McCaffrey will play, listing him as a game-time decision.
• The 49ers will also see the return of key players Trent Williams and Brandon Aiyuk after contract disputes.
• Defensive end Yetur Gross-Matos and linebacker Dee Winters are ruled out for the game.
• Safety Talanoa Hufanga is doubtful as he recovers from an ACL injury.