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2w ago

Childhood Gut Bacteria Linked to Rising Early-Onset Colorectal Cancer Rates

New research identifies colibactin, a toxin produced by certain E. coli strains, as a key driver of DNA mutations in early-onset bowel cancer cases, sparking efforts to develop diagnostic and preventive solutions.

Escherichia coli that resides in the digestive tract of humans and warm-blooded animals.
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Increased consumption of ultra-processed foods can impact children’s gut health and immunity, leaving them more susceptible to the bacteria.
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Overview

  • Global rates of early-onset colorectal cancer are increasing, with England reporting a 3.6% annual rise in cases among those under 50.
  • A toxin called colibactin, produced by specific strains of E. coli, has been identified as a major contributor to DNA mutations linked to early-onset bowel cancer.
  • Mutations caused by colibactin typically occur within the first 10 years of life, suggesting early childhood exposure as a critical factor in cancer development decades later.
  • Researchers are developing stool-based tests to detect colibactin-related mutations and exploring probiotic treatments to reduce harmful bacterial strains in the gut.
  • Projections indicate that if current trends persist, colorectal cancer could become the leading cause of cancer-related deaths among young adults by 2030.