The AFC West opener between Kansas City and Los Angeles features Patrick Mahomes against Justin Herbert at Neo Química Arena in São Paulo. Kickoff is Friday, September 5 at 18:00 Mexico City time (20:00 ET), matching a prime-time viewing window. Fans in Mexico can watch free on the NFL’s YouTube channel, with the game also available on DAZN via NFL Game Pass. This is the league’s second regular-season game in Brazil, anchoring an expanded 2025 International Series. The Friday slot is designed to maximize global reach, and Karol G is confirmed for the halftime show.