Overview
- Kickoff is set for 8:20 p.m. ET on Sept. 20 and the game will air on NBC with Mike Tirico and Cris Collinsworth while streaming options include Peacock, Fubo and Sling.
- Sportsbooks list the Chiefs as roughly a 5.5–6.5 point favorite and the over/under is about 45.5–46.5, and several predictive models give Kansas City about a 70% chance to win.
- Kansas City opened 1-0 after a 31-10 win over Denver in Week 1 when Patrick Mahomes returned from a season-ending knee injury and Kenneth Walker totaled 191 yards and two touchdowns in a breakout performance.
- The Colts enter 0-1 after a 41-23 loss to Baltimore and carry an eight-game losing streak with clear defensive issues that analysts say will be tested by Kansas City's balanced attack.
- Key things to watch are Mahomes' planned workload to protect his knee, how heavily Kansas City leans on Walker on the ground, and whether the Colts can generate consistent pressure and takeaways to change the game flow.