Overview
- Patrick Mahomes went 15-of-34 for 250 yards with an interception, finishing under 50% completions for the first time in his career as Buffalo pressured him on 52.6% of dropbacks and sacked him three times.
 - The loss drops Kansas City outside the AFC playoff field at 5-4 and is its fourth one-score defeat after going 12-0 in such games last season.
 - Mahomes urged greater consistency and dismissed playoff rematch talk, saying the Chiefs must qualify first: "We’ve got to get there first."
 - RB Isiah Pacheco (sprained MCL) sat out but is expected back after the bye, OT Jawaan Taylor injured his right ankle and awaits further evaluation, and Clyde Edwards-Helaire was elevated for depth.
 - Josh Allen completed 23 of 26 passes for 273 yards and James Cook rushed for 114, underscoring offensive protection and defensive issues Kansas City must correct during the break.