Overview

• Kickoff is 8 p.m. ET at Corinthians Arena in São Paulo with a national stream on YouTube.
• Chargers running back Najee Harris is cleared after an eye injury, left tackle Rashawn Slater is out for the season, and Joe Alt moves to protect Justin Herbert’s blind side.
• Kansas City will be without top receiver Rashee Rice as he begins a six-game suspension, and rookie Jalen Royals is out with a knee injury as Marquise Brown and Xavier Worthy take on larger roles.
• BetMGM lists the Chiefs as 3-point favorites, and most previews anticipate a close, lower-scoring game driven by two strong defenses.
• The Chiefs have won seven straight against Los Angeles, Justin Herbert faces fresh scrutiny entering Week 1, and Jim Harbaugh is 5-0 in season openers.