Overview

• Hampton injured his left ankle in Sunday’s 27-10 loss to Washington, exited in the third quarter and was seen in a walking boot afterward.
• Head coach Jim Harbaugh confirmed Monday that the first-round pick is going on injured reserve, making Week 10 the earliest possible return under NFL rules.
• The rookie had become the lead back, posting 314 rushing yards, two touchdowns and 20 receptions through five games.
• With Hampton sidelined and Harris already out, Hassan Haskins and Kimani Vidal are the top in-house options, with Amar Johnson on the practice squad as the team evaluates outside additions.
• Injuries on the offensive line, including Rashawn Slater’s season-ending knee injury and Joe Alt’s high ankle sprain, further complicate the Chargers’ run game heading into Week 6 at Miami.