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2w ago

Chargers Installed as Road Favorites Over Winless Giants in Week 4

Betting confidence reflects a 3-0 Chargers team facing one of the league’s weakest defenses.

Will Russell Wilson and the New York Giants beat the Los Angeles Chargers on Sunday? NFL Week 4 predictions, picks, odds preview the game on Sept. 28, 2025.

Overview

  • Los Angeles visits MetLife Stadium on Sunday, Sept. 28, with kickoff at 1 p.m. ET on CBS.
  • Sportsbooks list the Chargers by roughly 5.5 to 6.5 points with a moneyline near -250 to -275 and totals around the mid‑40s.
  • After Najee Harris’s season-ending Achilles injury, rookie Omarion Hampton steps into an expanded lead role for the Chargers.
  • The Giants are accelerating rookie Jaxson Dart’s involvement after Russell Wilson’s uneven start, with local coverage pointing to increased snaps.
  • Through three games the Giants rank 31st in total and rush defense, while Justin Herbert’s efficient passing has powered Los Angeles to a 3-0 start and consensus predictions lean toward the Chargers.