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2w ago

Chargers Enter Week 4 as Road Favorites vs. Winless Giants

Odds and expert projections tilt toward Los Angeles following New York's 0-3 start.

Will Russell Wilson and the New York Giants beat the Los Angeles Chargers on Sunday? NFL Week 4 predictions, picks, odds preview the game on Sept. 28, 2025.

Overview

  • The game kicks off Sunday, Sept. 28 at 1 p.m. ET on CBS, and sportsbooks make Los Angeles roughly a 5.5-point favorite with moneylines around -250 to -275.
  • Los Angeles is 3-0 after an AFC West sweep, while New York fell to 0-3 with a 22-9 loss to the Chiefs.
  • Models and pundits largely back the Chargers, with ESPN’s projection giving them about a 67.7% chance to win.
  • Justin Herbert has opened with 898 passing yards and eight touchdowns in three games, and the Chargers defense has generated five takeaways over the last two contests.
  • Russell Wilson’s 160-yard outing has intensified scrutiny of the Giants offense, with local coverage suggesting rookie Jaxson Dart could see expanded snaps.