Overview

• The peer‑reviewed analysis integrated genome, epigenome, proteome, metabolome and gut microbiota from blood, saliva, urine and stool collected in her final year.
• Epigenetic clocks estimated a biological age far below her 117 years, with one ribosomal‑DNA clock placing her roughly 23 years younger.
• Her gut community showed youth‑like features dominated by Bifidobacterium, a pattern the team links to daily yogurt consumption.
• Sequencing revealed an exceptional genetic profile enriched for protective variants, including seven rare changes not observed in examined European controls.
• The dataset also captured hallmarks of advanced ageing—very short telomeres, inflammatory immune shifts and clonal haematopoiesis—reinforcing the dual picture and the authors’ call for larger comparative studies before clinical translation.