Overview
- Authors of the CDC’s Emerging Infectious Diseases review recommend classifying Chagas as endemic (hypoendemic) in parts of the United States to drive public‑health action.
- Locally acquired human infections have been confirmed in Texas, California, Arizona, Louisiana, Tennessee, Missouri, Mississippi and Arkansas.
- Most states do not require clinicians to report Chagas, leaving national data inconsistent and likely undercounting infections estimated at roughly 300,000 people.
- In Texas, more than 50 local human cases were documented from 2013 to 2023, with some dog kennels showing about 31% infection, indicating entrenched transmission cycles.
- Transmission typically follows contact with infected triatomine feces, with additional risks from congenital, blood transfusion and organ transplant routes; benznidazole and nifurtimox remain the primary approved treatments.