Overview
- Khon Kaen University scientists reported findings on December 15 in Frontiers in Pharmacology after testing cannabis compounds on human ovarian cancer cells.
- CBD and THC each reduced colony formation, while a 1:1 CBD:THC combination showed synergy, induced cancer cell death, and limited cell migration in vitro.
- The anti-cancer activity was observed in both platinum-sensitive and platinum-resistant ovarian cancer cell lines.
- Healthy cells were minimally affected by the treatments in vitro, indicating selective toxicity toward cancer cells.
- Mechanistic assays indicated reduced PI3K/AKT/mTOR pathway signaling and restoration of a tumor-suppressor protein, with authors emphasizing the need for in vivo and pharmacokinetic studies and noting regulatory hurdles.