Overview
- Left tackle Paris Johnson Jr. is inactive with a knee injury, with veteran Kelvin Beachum set to start in his place.
- Arizona activated cornerback Max Melton, while cornerback Will Johnson is inactive and Garrett Williams remains on injured reserve until at least Week 7.
- Cornerback Elijah Jones is active and will make his NFL debut.
- The Cardinals elevated offensive lineman Jake Curhan and defensive lineman Anthony Goodlow from the practice squad, with Curhan available as a versatile backup alongside Josh Fryar and Jon Gaines.
- San Francisco will be without quarterback Brock Purdy and wide receiver Jauan Jennings.