Cannabinol Found to Enhance Sleep Quality in New Study

University of Sydney researchers provide first objective evidence of cannabinol's sleep-inducing effects in rats, paving the way for potential human applications.

• The study, published in Neuropsychopharmacology, shows that cannabinol (CBN) increases both NREM and REM sleep in rats.
• CBN, a breakdown product of THC, is more prevalent in older cannabis and has been linked to a sleepier effect.
• Unlike THC, CBN does not intoxicate, as it weakly activates the brain's CB1 cannabinoid receptors.
• The research suggests CBN's metabolite, 11-OH CBN, has a significant impact on sleep-related brain areas.
• A parallel human trial on CBN's effects in insomnia patients has shown promising results, indicating further research is needed.

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