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California Confirms First U.S. Local Spread of More Severe Clade I Mpox

Health officials report limited transmission in the Los Angeles area, with vaccination drives plus contact tracing underway.

Overview

  • Three unrelated infections were identified in one Long Beach resident and two Los Angeles County residents, all initially hospitalized and now recovering at home.
  • State and county health departments say person‑to‑person transmission is occurring locally, with cases concentrated among gay and bisexual men.
  • Officials describe overall risk to the general public as low, while the CDC rates risk for men who have sex with multiple partners as low to moderate.
  • The two‑dose Jynneos vaccine is available to higher‑risk groups, and second doses can be given regardless of the time since the first dose.
  • Experts warn reduced outbreak response capacity could hinder rapid detection, sequencing and containment efforts as surveillance expands.