Buffalo Bills Host San Francisco 49ers in Week 13 Showdown

The Bills aim to extend their six-game win streak, while the injury-plagued 49ers look to rebound after two straight losses.

The Buffalo Bills (9-2) will face the San Francisco 49ers (5-6) on Sunday night at Highmark Stadium in Orchard Park, New York.
Buffalo enters the game riding a six-game win streak, scoring 30 or more points in their last five outings and leading the league in turnover differential at +14.
The 49ers have struggled with injuries, including quarterback Brock Purdy (shoulder) and key players like Nick Bosa and Trent Williams, but Purdy is expected to return this week.
San Francisco’s offense, ranked fourth overall, has seen a decline in rushing efficiency since Christian McCaffrey’s return, averaging 3.85 yards per carry over the last three games.
The Bills are favored by seven points, with analysts predicting Buffalo's strong form and home-field advantage will be too much for the inconsistent 49ers.