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Bryan Johnson Takes High-Dose Psilocybin in Public Self-Experiment on Aging

He says the supervised session will be followed by monthly dosing to measure longevity markers.

Overview

  • Johnson ingested about 4.67 to 5 grams of magic mushrooms containing roughly 24.9 mg of psilocybin, with Blueprint co-founder Kate Tolo documenting the session as his trip-sitter.
  • During the experience, his team recorded on-the-spot measures including a brain scan, blood pressure, and an adrenal stress saliva profile, and he later submitted blood samples.
  • He reported intense sensory changes, visual distortions, a warped sense of time, and a momentary perception that his heart had stopped, later saying he felt rejuvenated and mentally sharper.
  • He plans to repeat dosing once a month for three months while testing around 240 biomarkers, though no biomarker findings have been released.
  • Johnson says the session occurred under medical supervision in a legal setting; coverage also notes psilocybin’s U.S. federal Schedule I status and cites preliminary mouse data from Baylor and Emory as context rather than human evidence.