Overview

• Kickoff is Sunday, Sept. 14 at 4:05 p.m. ET at Lucas Oil Stadium on CBS with streaming on Paramount+.
• Colts ruled out starting CB Charvarius Ward (concussion) and backup Jaylon Jones (hamstring), while DE Laiatu Latu (hamstring) is questionable after two straight DNPs.
• Broncos ruled out LB Dre Greenlaw (quad) and TE Nate Adkins (ankle), with TE Evan Engram, DL John Franklin-Myers and LB Alex Singleton cleared to play.
• Sportsbooks list Denver as a slight road favorite at roughly -2 to -2.5 in a meeting of 1-0 teams after the Broncos opened with six sacks.
• Indianapolis seeks its first 2-0 start since 2009 behind Daniel Jones and standout rookie TE Tyler Warren, with Mekhi Blackmon and Johnathan Edwards set for larger roles at corner.