Overview
- Kickoff is 4:05 p.m. ET at Lucas Oil Stadium on CBS4, with Denver a 2.5-point road favorite.
- Denver opened with a defense-led win over Tennessee, piling up six sacks and holding the Titans to 133 total yards as Nik Bonitto logged his first sack of 2025.
- Daniel Jones impressed in his Colts debut by going 22-of-29 for 272 yards with one passing touchdown and two rushing scores.
- Indianapolis will be without cornerbacks Charvarius Ward (concussion) and Jaylon Jones (hamstring, IR), a setback as Courtland Sutton leads Denver’s receiving corps.
- Preview coverage highlights Patrick Surtain II as a defensive anchor for Denver and notes Fox59’s projection calling for a Colts upset, 24–21.