Brock Purdy Set to Start for 49ers Against Bills Despite Shoulder Injury

The quarterback returns after missing his first NFL game, but San Francisco faces significant roster challenges in snowy Buffalo.

49ers quarterback Brock Purdy will start against the Buffalo Bills after recovering from a shoulder injury that sidelined him in Week 12.
San Francisco will be without key starters, including left tackle Trent Williams, left guard Aaron Banks, and defensive end Nick Bosa, due to injuries.
Purdy's return follows a full practice on Friday, marking his first since being injured during a Week 11 loss to the Seattle Seahawks.
Backup Brandon Allen struggled in Purdy's absence last week, with the 49ers suffering their worst defeat in six years, a 38-10 loss to Green Bay.
Snowy and windy conditions are expected for the Sunday night matchup, adding further challenges to an already injury-depleted 49ers lineup.