Overview

• 49ers quarterback Brock Purdy will start against the Buffalo Bills after recovering from a shoulder injury that sidelined him in Week 12.
• San Francisco will be without key starters, including left tackle Trent Williams, left guard Aaron Banks, and defensive end Nick Bosa, due to injuries.
• Purdy's return follows a full practice on Friday, marking his first since being injured during a Week 11 loss to the Seattle Seahawks.
• Backup Brandon Allen struggled in Purdy's absence last week, with the 49ers suffering their worst defeat in six years, a 38-10 loss to Green Bay.
• Snowy and windy conditions are expected for the Sunday night matchup, adding further challenges to an already injury-depleted 49ers lineup.