Overview
- Purdy went 19-of-26 for 200 yards with no interceptions in his first start since Week 4.
- Christian McCaffrey scored three times, including two rushing touchdowns and a 9-yard reception.
- George Kittle caught two touchdowns and reached 50 career scores, joining Jerry Rice and Terrell Owens as 49ers with 50 touchdowns and 500 receptions.
- The Cardinals committed 17 penalties for a franchise record and the most by any NFL team this season, while Jacoby Brissett set the regular-season mark with 47 completions for 452 yards.
- San Francisco reported kicker Eddy Piñeiro as questionable with a right hamstring injury, with additional in-game exits for Tatum Bethune (ankle) and Robert Beal Jr. (concussion).