Overview

• Head coach Kyle Shanahan said Purdy, a full participant Friday and off the injury report, will start after missing two games with toe and shoulder issues.
• Backup Mac Jones has been cleared to play and will serve as QB2 after going 2-0 with 563 yards, four touchdowns and one interception in Purdy’s absence.
• Wideout Ricky Pearsall has been cleared to play, Jauan Jennings remains questionable after a limited return to practice, and Demarcus Robinson has been activated to reinforce receiver depth.
• Nick Bosa underwent ACL surgery and is out for the season, and GM John Lynch said Brandon Aiyuk is not close to returning from last year’s knee injuries.
• San Francisco enters Week 4 unbeaten with the NFL’s top passing yardage, drawing a Jaguars defense ranked fifth in points allowed.