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32m ago

Brock Purdy Cleared to Start as 49ers Host Jaguars in Week 4

San Francisco enters Week 4 unbeaten despite Nick Bosa’s season-ending ACL and Brandon Aiyuk’s prolonged absence.

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NEW ORLEANS, LA - SEPTEMBER 14: Nick Bosa #97 and Alfred Collins #95 of the San Francisco 49ers tackle Alvin Kamara #41 of the New Orleans Saints during the game at the Caesars Superdome on September 14, 2025 in New Orleans, Louisiana. The 49ers defeated the Saints 26-21. (Photo by Michael Zagaris/San Francisco 49ers/Getty Images)
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Overview

  • Purdy missed two games with a turf-toe variant and a left (non-throwing) shoulder issue, practiced fully Friday, and carries no injury designation for Sunday.
  • Backup Mac Jones has been cleared to dress after a knee scare and returns to QB2 duties following two wins with 563 passing yards, four touchdowns, and one interception.
  • Top wideouts Ricky Pearsall and Jauan Jennings are expected to play after being listed questionable, with reporting indicating Jennings will likely have a limited workload.
  • The 49ers confirmed Nick Bosa underwent ACL surgery and is out for the season, and GM John Lynch said Brandon Aiyuk is not close to returning.
  • San Francisco is 3-0 entering the home matchup with Jacksonville at 4:05 p.m. ET, facing a Jaguars defense ranked fifth in points allowed.