Overview

• Service begins April 19, 2026, with four flights per week during the summer operated by Boeing 787-8s offering business, premium economy and economy cabins.
• Published schedule lists BA221 departing Heathrow at 16:25 and arriving St. Louis at 19:30, with BA220 leaving St. Louis at 22:00 and reaching London at 12:05 the next day.
• St. Louis becomes British Airways’ 27th U.S. destination, and the carrier will be the only UK airline offering a direct link to the city.
• Regional officials welcomed the launch for its connectivity and potential economic impact, with industry benchmarks citing $50 million to $100 million in annual gains.
• The route restores nonstop UK access last seen in 2003 and complements Lufthansa’s existing Frankfurt–St. Louis service.