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Brief Intense Exercise Alters Blood Signals That Affect Bowel Cancer Cells, Study Finds

A small Newcastle study found post-exercise blood altered cancer-cell gene activity in the lab, not in patients.

Overview

  • Researchers drew blood from 30 overweight or obese men before and after a 10–12 minute cycling bout and tested its effects on cultured bowel cancer cells.
  • Post-exercise samples showed increases in 13 proteins linked to lower inflammation, improved vascular function, metabolism, and DNA repair.
  • When applied to cancer cells, the post-exercise serum shifted the activity of 1,364 genes tied to energy production, DNA repair, and cell growth.
  • The authors say the findings, published in the International Journal of Cancer, offer a mechanistic clue that complements epidemiological links between activity and lower risk.
  • The team plans studies on repeated exercise and interactions with chemotherapy or radiotherapy, while stressing that the laboratory results are preliminary.