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Breast Cancer Mortality in Younger Women Falls Sharply, but Disparities Persist

New data reveal a 10-year decline in breast cancer deaths among U.S. women aged 20–49, driven by targeted therapies and expanded screening, though racial gaps remain significant.

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Overview

  • Breast cancer deaths among women aged 20–49 in the U.S. declined from 9.70 to 1.47 per 100,000 between 2010 and 2020, with the steepest drops after 2016.
  • Luminal A breast cancer showed the greatest decline in mortality, but younger women with this subtype had worse 10-year survival rates compared to older women and other subtypes.
  • Non-Hispanic Black women experienced the highest mortality rates in 2010 and 2020, with survival outcomes lagging behind other racial and ethnic groups.
  • Advances in treatment, including CDK4/6 inhibitors and optimized endocrine therapies introduced after 2015, significantly contributed to improved outcomes for hormone receptor-positive cancers.
  • Expanded screening for women aged 40–49 and targeted approaches for high-risk younger women have improved early detection, though access disparities remain a challenge.