Breakthrough Study Reveals snoRNA's Role in Protein Secretion and Therapeutic Potential
University of Chicago researchers uncover thousands of new snoRNA targets, expanding their known functions and paving the way for innovative medical applications.
- Scientists identified thousands of previously unknown snoRNA targets in human cells and mouse brain tissues using a novel technique called snoKARR-seq.
- The study revealed that snoRNA SNORA73 facilitates protein secretion by acting as a molecular glue between mRNA and protein synthesis machinery.
- Engineered snoRNA sequences increased protein secretion by 30–50%, demonstrating potential for therapeutic applications in diseases involving protein deficiencies.
- The findings suggest snoRNAs have broader cellular functions beyond their traditional role in guiding ribosomal RNA modifications.
- Researchers see significant opportunities for future studies into snoRNA's diverse roles across various cell types, including neurons, stem cells, and cancer cells.
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