Overview

• Scientists identified thousands of previously unknown snoRNA targets in human cells and mouse brain tissues using a novel technique called snoKARR-seq.
• The study revealed that snoRNA SNORA73 facilitates protein secretion by acting as a molecular glue between mRNA and protein synthesis machinery.
• Engineered snoRNA sequences increased protein secretion by 30–50%, demonstrating potential for therapeutic applications in diseases involving protein deficiencies.
• The findings suggest snoRNAs have broader cellular functions beyond their traditional role in guiding ribosomal RNA modifications.
• Researchers see significant opportunities for future studies into snoRNA's diverse roles across various cell types, including neurons, stem cells, and cancer cells.