Overview

• The Phase 1/2 trial, published in *Nature*, demonstrated meaningful upper-limb recovery in 19 chronic cervical spinal cord injury patients using closed-loop vagus nerve stimulation (CLV).
• Participants showed significant gains in arm and hand function when CLV was paired with individualized rehabilitation, which therapy alone could not achieve.
• The miniaturized wireless implant, 50 times smaller than prior versions, enables compatibility with imaging technologies and simplifies surgical procedures.
• The therapy proved effective regardless of participants' age, time since injury, or initial impairment severity, offering hope for a wide range of patients.
• Preparations are underway for a pivotal Phase 3 trial involving 70 participants across U.S. spinal cord injury centers to seek FDA approval.