Breakthrough in Male Contraception: Reversible, Non-Hormonal Method Discovered

Scientists at the Salk Institute identify a novel approach to male birth control that does not affect libido and is fully reversible.

Scientists at the Salk Institute have discovered a new method for reversible, non-hormonal male birth control by targeting a protein complex involved in sperm production.
The method uses HDAC inhibitors to interrupt sperm production without affecting libido, offering a promising alternative to condoms and vasectomies.
Treatment with HDAC inhibitors in male mice resulted in temporary infertility, with fertility fully restored within 60 days after ceasing treatment.
This approach does not damage sperm stem cells or their genomic integrity, ensuring the health of subsequent offspring.
The discovery opens the door for human clinical trials and represents a significant advancement in male contraceptive options.