Breakthrough in Drugging Previously 'Undruggable' Enzymes

UCSF researchers discover new method to target GTPases, opening potential treatments for Parkinson's, cancer, and more.

• Scientists engineered mutations in GTPases to identify new drug binding sites.
• The approach revealed binding sites that computational tools could not predict.
• This discovery builds on previous work targeting the cancer-related K-Ras GTPase
• The method involves using existing drugs and chemical genetics to freeze GTPases in an inactive state.
• Researchers hope sharing their methods will accelerate drug discovery for various diseases.

3 Articles

GEN ScienceDaily Phys.org