Overview
- Scientists have created a broad-spectrum antivenom using antibodies from Tim Friede, who self-immunized with venom from 16 deadly snake species over 18 years.
- The antivenom combines two human antibodies with a small-molecule inhibitor, providing full protection in mouse trials against venom from 13 of 19 WHO-listed elapid snake species.
- This new approach addresses limitations of traditional antivenoms, which rely on horse-derived antibodies, are species-specific, and carry risks of allergic reactions.
- The antivenom’s success in preclinical trials has prompted plans to test its efficacy in dogs at Australian veterinary clinics, with future development aimed at viper venoms.
- Snakebite, classified as a neglected tropical disease, causes 138,000 deaths and 400,000 maimings annually, disproportionately affecting rural, low-income populations.